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李广悦

      

国外正规买球app 研究员, 博士生导师, 中国农业科学院“植物病害生物防治”创新团队首席科学家,中国农业科学院青年英才“A”类入选者。2003-2007年就读于河北农业大学生命学院并获得学士学位,2007-2010年就读于国外正规买球app并获得硕士学位,2010-2014年就读于中国科学院天津工业生物技术研究所并获得博士学位。2014-2017年在德国马普煤炭所Manfred.T.Reetz教授实验室从事博士后研究。2017年11月回国,入职国外正规买球app。主要从事线虫共生细菌中抗菌活性物质的发掘、代谢途径优化以及代谢途径中关键酶的定向改造等研究。在JACS、ACS Catalysis、Chemical Science、Chemical Communications等学术期刊上发表文章30多篇. 

E-mail: liguangyue@caas.cn


已发表文章

1. Y. Dong#, T. Li#, S. Zhang#, J. Sanchis, H. Yin, J. Ren, X. Sheng*, G. Li*, M. T. Reetz*. Biocatalytic Baeyer-Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis, 2022, 12 , 3669-3680.

2. Zhao Mingqi, Wang Miao*, Zhang Xiaoguang, Zhu Yongan, Cao Jing, She Yongxin, Cao Zhen, Li Guangyue*, Wang Jing*,Abd A. M. Recognition elements based on the molecular biological techniques for detecting pesticides in food: A review. Critical Reviews in Food Science and Nutrition, 2021, 1-24.

3. Youcai Qin, Fenglian Jia, Xiaohui Li, Beibei Li, Jie Ren, Xiufen Yang and Guangyue Li*. Improving the Yield of Xenocoumacin 1 by PBAD Promoter Replacement in  Xenorhabdus nematophila CB6. Agriculture, 2021, 11: 1251.

4. Li, G#.; Qin, Y#.; Fontaine, N. T#.; Ng Fuk Chong, M.; Maria‐Solano, M. A.; Feixas, F.; Cadet, X. F.; Pandjaitan, R.; Garcia‐Borràs, M.; Cadet, F., Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation. ChemBioChem. 2020, 21,1-12.

5. 李广悦, 杨秀芬. 嗜线虫致病杆菌抗菌代谢产物 Xcn1 的研究进展. 中国生物防治学报 2020, 36 (1), 1-8.

6. Dong, Y.; Li, X.; Duan, J.; Qin, Y.; Yang, X.; Ren, J.; Li, G*. Improving the Yield of Xenocoumacin 1 Enabled by In Situ Product Removal. ACS omega .  2020, 5(32), 20391–20398.

7. Jiaqi Duan, Beibei Li, Youcai Qin, Yijie Dong, Jie Ren and Guangyue Li*. Recent progress in directed evolution of stereoselective monoamine oxidases. Bioresources and Bioprocessing [J]. 2019, 6: 1-11.

8. Guangyue Li, Yijie Dong, and Manfred T. Reetz*. Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes? Adv. Synth. Catal [J]. 2019, 361, 2377 – 2386.

9. Yijie Dong#, Peiyuan Yao#, Yunfeng Cui, Qiaqing Wu, Dunming Zhu*, Guangyue Li*and Manfred T. Reetz*. Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols. Biological Chemistry [J]. 2019,400(3), 313-321.

10. Guangyue Li, Marc Garcia-Borràs, Maximilian J. L. J. Fürst, Adriana Ilie, Marco W. Fraaije, K. N. Houk*and Manfred T. Reetz*. Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution. JACS [J]. 2018, 140, 10464?10472.

11. Guangyue Li#, Peiyuan Yao#, Rui Gong#, Jinlong Li, Pi Liu,Richard Lonsdale, Qiaqing Wu, Jianping Lin*,Dunming Zhu* and Manfred T. Reetz*. Simultaneous engineering of an enzyme’s entrance tunnel and active site: The case of monoamine oxidase MAO-N. Chemical Science [J]. 2017, 8,4093-4099.

12. Guangyue Li, Miguel A. Maria-Solano, Adrian Romero-Rivera, Sílvia Osuna* and Manfred T. Reetz*. Inducing High Activity of a Thermophilic Enzyme at Ambient Temperatures by Directed Evolution. Chemical Communications [J]. 2017, 53,9454-9457.

13. Guangyue Li, M.J. L. J. Fürst, H. R. Mansouri, A. K. Ressmann, A. Ilie, F. Rudroff, M. D. Mihovilovic*, M.W. Fraaije* and M. T. Reetz*. Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution. Organic & Biomolecular Chemistry [J]. 2017,15,9824-9829.

14. Guangyue Li, Jianbo Wang and Manfred T. Reetz*. Biocatalysts for the pharmaceutical industry generated by structure-guided directed evolution ofstereoselective enzymes. Bioorganic & Medicinal Chemistry [J]. 2017, 7(26), 1241-1251.

15. Guangyue Li#, Hui Zhang#, Zhoutong Sun, Xinqi Liu and Manfred T. Reetz*. Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase. ACS Catalysis [J]. 2016, 6(6), 3679?3687.

16. Guangyue Li and Manfred T. Reetz*. Learning Lessons from Directed Evolution of Stereoselective Enzymes. Org. Chem. Front [J]. 2016. 3, 1350-1358.

17. Guangyue Li#, Peiyuan Yao#, Peiqian Cong, Jie Ren, Lei Wang, Jinhui Feng, Peter C.K. Lau, Qiaqing Wu*,and Dunming Zhu*. New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates. Scientific reports [J]. 2016,6:24973.

18. Guangyue Li#, Jie Ren#, Peiyuan Yao,Yitao Duan, Hailing Zhang, Qiaqing Wu, Jinhui Feng, Peter CK Lau*, Dunming Zhu*. Deracemization of 2-Methyl-1, 2, 3, 4-tetrahydroquinoline Using Mutant Cyclohexylamine Oxidase Obtained by Iterative Saturation Mutagenesis. ACS Catalysis [J]. 2014, 4,903-908.

19. Guangyue Li, Jie Ren, Hiroaki Iwaki, Dalong Zhang, Yoshie Hasegawa, Qiaqing Wu, Jinhui Feng, Peter C. K. Lau* and Dunming Zhu*. Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines. Applied Microbiology and Biotechnology [J]. 2014, 98(4),1681-1689.

20. Guangyue Li, Jie Ren, Qiaqing Wu*, Jinhui Feng, Dunming Zhu*, Yanhe Ma. Identification of a marine NADPH-dependent aldehyde reductase for chemoselective reduction of aldehydes. Journal of molecular catalysis B, Enzymatic [J], 2013, 90,17-22.



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