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李.方.方

      

李.方.方,现任国外正规买球app研究员,硕士生/博士生导师。2018年入选国外正规买球app‘青年英才计划引进工程’;2019年入选‘国家海外高层次引进人才’;2020年入选“中国农业科学院巾帼建功标兵”;2021年入选农业农村部“农业科研杰出人才”培养计划,兼任Frontiers in Microbiology期刊的Associate Editor、Frontiers in Plant Science等期刊的Review Editor等职务。

2009年获南京农业大学植物保护专业学士学位,2014年获浙江大学植物病理学专业博士学位。2014-2015年在浙江大学从事博士后研究,2015-2018年在加拿大农业与农业食品部先后从事博士后、助理研究员工作。2018年引进至国外正规买球app植物病虫害生物学国家重点实验室植物与病毒互作组工作。

主要从事植物与病毒的互作研究,通过解析植物病毒致病与寄主抗病的机理,研发植物病毒病害的绿色防控技术。先后主持国家重点研发项目、国家高层次人才项目、国家自然科学基金面上项目等项目8项,参与国家科技部973计划课题、国家自然科学基金重大/重点项目、加拿大农业部与加拿大自然科学与工程研究委员会资助的多项课题。

实验室以烟草、拟南芥、番茄和油菜为实验材料,以世界上:ψ钗现、种类最多的两类植物病毒:双生病毒科病毒和马铃薯Y科病毒为研究对象,开展寄主植物与病毒的互作方面的工作。涉及的寄主途径包含DNA修饰、RNA修饰与降解、蛋白质翻译后修饰与降解等。发表论文/著作40余篇,以通讯作者/第一作者身份在Nature Communications (2篇)、Trends in Microbiology(2篇)、Molecular Plant(1篇)、PLoS Pathogens(4篇)、New Phytologist(4篇)、Plant Physiology(1篇)、The Plant Journal(1篇)等刊物发表高水平论文29篇(其中9篇影响因子大于10);以参与作者身份在Trends in Plant Science、The Plant Cell等专业杂志上发表SCI收录论文12篇;研究成果获‘中国农业科学院科学技术成果奖’1项(第一完成人)、‘国外正规买球app2021年重大科技成果奖’1项(第二完成人)、获国家发明专利授权7项(第一完成人)。

联系电话:010-62816620

邮箱: ffli@ippcaas.cn


代表性论文(#共同第一作者,*共同通讯作者)

[1] Pan Gong, Siwen Zhao, Hui Liu, Zhaoyang Chang, Fangfang Li*, Xueping Zhou*. Tomato yellow leaf curl virus V3 protein traffics along microfilaments to plasmodesmata to promote virus cell-to-cell movement. Science China-Life Sciences (2022) . 27(9):792-805. (IF="6.038)

[2] Yushuang Guo, Meng-ao Jia, Shaofang Li*, Fangfang Li*. Geminiviruses boost active DNA demethylation for counter-defense.  Trends in Microbiology  (2022)  (IF="18.337)

[3] Mingzhen Zhang#, Pan Gong#, Linhao Ge#, Yinzi Li, Zhaoyang Chang, Rui Qiao, Xueping Zhou, Aiming Wang*, Fangfang Li*. Nuclear exportin 1 (XPO1) binds to the nuclear localization/export signal of the turnip mosaic virus NIb to promote viral infection.  Frontiers in Microbiology  (2021). 12:780724. (IF=6.32)

[4] Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li*, Xueping Zhou*. Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection.  PLoS Pathogens  (2021), 17(9): e1009956. (IF="7.455)

[5] Pan Gong, Huang Tan, Siwen Zhao, Hao Li, Hui Liu, Yu Ma, Xi Zhang, Junjie Rong, Xing Fu, Rosa Lozano-Durán*, Fangfang Li*, Xueping Zhou*. Geminiviruses encode additional small proteins with specific subcellular localizations and virulence function.  Nature Communications  (2021), 12(1):4278. (IF=15.805)

[6] Mingzhen Zhang, Pan Gong, Linhao Ge, Zhaoyang Chang, Xiaofei Cheng, Xueping Zhou, Aiming Wang, Fangfang Li*. Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity.  New Phytologist (2021), 232(3):1382-1398. (IF="10.476)

[7] Yongsen Cao, Huanbin Zhou, Xueping Zhou, Fangfang Li*. Conferring resistance to plant RNA viruses with the CRISPR/CasRx system. Virologica Sinica (2021), 36(4):814-817. (IF="4.327)

[8] Fangfang Li*, Mingzhen Zhang, Changwei Zhang, Xueping Zhou. Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in Solanaceous plants.  New Phytologist (2020), 225(4): 1746-1761. (IF="10.476)

[9] Fangfang Li#, Changwei Zhang#, Ziwei Tang, Lingrui Zhang, Zhaoji Dai, Shanwu Lyu, Yinzi Li, Xilin Hou, Mark Bernards, Aiming Wang*. A plant RNA virus activates selective autophagy in a UPR-dependent manner to promote virus infection.  New Phytologist (2020), 228(2):622-639.  (IF="10.476)

[10] Fangfang Li, Aiming Wang*. RNA-targeted antiviral immunity: more than just RNA silencing.  Trends in Microbiology  (2019), 27(9):792-805. (IF="18.337)

[11] Fangfang Li, Wende Liu, Xueping Zhou*. Pivoting plant immunity from theory to the field.  Science China-Life Sciences (2019), 62(11):1539-1542. (IF="6.038)

[12] Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou, Aiming Wang*. Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase.  Nature Communications  (2018), 9(1):1268. (IF="15.805)

[13] Fangfang Li, Xiuling Yang, David M Bisaro, Xueping Zhou*. The βC1 protein of geminivirus-betasatellite complexes: A target and repressor of host defenses.  Molecular Plant  (2018), 11:1424-1426. (IF="16.357)

[14] Fangfang Li, Aiming Wang*. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors.  PLoS pathogens (2018), 14.8: e1007228. (IF="7.455)

[15] Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou*. A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in  Nicotiana benthamiana .  PLoS Pathogens  (2017), 13(2): e1006213. (IF="7.455)

[16] Sang‐Ho Park#, Fangfang Li#, Justin Renaud, Wentao Shen, Yinzi Li, Lihua Guo, Hongguang Cui, Mark Sumarah, Aiming Wang*. NbEXPA1, an α-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection.  The Plant Journal (2017), 2(5): 846-861.  (IF=7.666)

[17] Fangfang Li, Yaqin Wang, Xueping Zhou*. SGS3 cooperates with RDR6 in triggering geminivirus-induced gene silencing and in suppressing geminivirus infection in  Nicotiana benthamiana .  Viruses (2017), 9 (9):247. (IF="5.048)

[18] Fangfang Li#, Xiongbiao Xu#, Changjun Huang, Zhouhang Gu, Linge Cao, Tao Hu, Ming Ding, Zhenghe Li, Xueping Zhou*. The AC5 protein encoded by mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses.  New Phytologist  (2015), 208(2):555-569.  (IF="10.476)

[19] Fangfang Li#, Weidi Wang#, Nan Zhao, Bingguang Xiao, Peijian Cao, Xingfu Wu, Chuyu Ye, Enhui Shen, Jie Qiu, Qian-Hao Zhu, Jiahua Xie, Xueping Zhou*, Longjiang Fan*. Regulation of nicotine biosynthesis by an endogenous target mimicry of microRNA in tobacco.  Plant Physiology (2015), 169(2): 1062-1071. (IF="8.972)

[20] Fangfang Li, Changjun Huang, Zhenghe Li, Xueping Zhou*. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression.  PLoS Pathogens (2014), 10: e1003921.  (IF="7.455)


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